Degraeve N, Chollet M C, Moutschen J
Environ Health Perspect. 1985 May;60:395-8. doi: 10.1289/ehp.8560395.
Male mice (Q strain) received two consecutive injections of organophosphorus insecticides: a phosphonate (trichlorfon) was combined to a thiophosphate (methylparathion) or a dithiophosphate (malathion or methylazinphos) in order to evaluate the interactions at the genetic and cytogenetic levels. No increase in chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes. In a dominant lethal mutation assay, the frequency of postimplantation lethality was not significantly increased over the control level. The percentage of preimplantation losses was enhanced, probably due to a toxic effect on male germ cells.
雄性小鼠（Q品系）连续接受两次有机磷杀虫剂注射：一种膦酸酯（敌百虫）与一种硫代磷酸酯（甲基对硫磷）或二硫代磷酸酯（马拉硫磷或保棉磷）联合使用，以评估在遗传和细胞遗传学水平上的相互作用。在骨髓细胞、精原细胞和初级精母细胞中未观察到染色体损伤增加。在显性致死突变试验中，植入后致死率未显著高于对照水平。植入前损失的百分比有所增加，可能是由于对雄性生殖细胞的毒性作用。
