Degraeve N, Chollet M C, Moutschen J
Toxicol Lett. 1984 Jun;21(3):315-9. doi: 10.1016/0378-4274(84)90090-0.
Male mice (Q strain) received a single i.p. injection of 14 organophosphorus compounds, including 11 insecticides, administered on separate occasions. After a recovery period of 10 to 15 days, the cytogenic effects were analyzed in primary spermatocytes at diakinesis-metaphase I corresponding to the treatment of A4-B type spermatogonia. At the highest tolerated dose, trimethylphosphate (1000 mg/kg), triethylphosphate (300 mg/kg), dichlorvos (10 mg/kg), methylparathion (10 mg/kg), ethylparathion (10 mg/kg), ethylparaoxon (0.3 mg/kg), fenitrothion (1000 mg/kg), methylbromophos (1000 mg/kg), ethylbromophos (1000 mg/kg), dimethoate (10 mg/kg), malathion (300 mg/kg), methylazinphos (1 mg/kg), ethylazinphos (1 mg/kg) and trichlorfon (100 mg/kg) did not produce chromosome damage.
雄性小鼠（Q品系）分别单次腹腔注射14种有机磷化合物，其中包括11种杀虫剂。在10至15天的恢复期后，对处于终变期-中期I的初级精母细胞进行细胞遗传学效应分析，该时期对应于A4-B型精原细胞的处理。在最高耐受剂量下，磷酸三甲酯（1000毫克/千克）、磷酸三乙酯（300毫克/千克）、敌敌畏（10毫克/千克）、甲基对硫磷（10毫克/千克）、乙基对硫磷（10毫克/千克）、乙基对氧磷（0.3毫克/千克）、杀螟硫磷（1000毫克/千克）、溴苯磷（1000毫克/千克）、乙基溴硫磷（1000毫克/千克）、乐果（10毫克/千克）、马拉硫磷（300毫克/千克）、甲基嘧啶磷（1毫克/千克）、乙嘧硫磷（1毫克/千克）和敌百虫（100毫克/千克）均未产生染色体损伤。
