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[产前缺氧后大鼠大脑的电活动]

[Electrical activity of the rat brain following antenatal hypoxia].

作者信息

Provodina V N, Dmitrieva O K

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1984 May-Jun;34(3):547-53.

PMID:6540938
Abstract

EEG and EPs in the visual and parietal neocortical areas and the hippocampus were studied in freely behaving rats at the age of two-three months after antenatal hypoxia. Increase of spectral power in delta and theta bands and its decrease in alpha and beta bands in the background EEG and in responses to a protracted light stimulation were observed in experimental animals in comparison to control ones. The most pronounced changes were observed in the parietal cortex and hippocampus. The character of changes in latencies and the share of individual EP components recorded point to an accelerated excitation reverberation in neuronal networks in response to afferent stimuli and to a prolongation of after-discharges in the parietal cortex and hippocampus testifying to peculiarity of information processing in these brain structures. On the basis of other authors' data, certain parallelism is supposed to exist between the electrophysiological parameters in experimental animals and some groups of children with mental retardation.

摘要

对产前缺氧后两到三个月大的自由活动大鼠的视觉和顶叶新皮质区域以及海马体中的脑电图(EEG)和诱发电位(EPs)进行了研究。与对照动物相比,实验动物在背景脑电图以及对长时间光刺激的反应中,观察到δ波和θ波频段的频谱功率增加,而α波和β波频段的频谱功率降低。在顶叶皮质和海马体中观察到最明显的变化。记录的潜伏期变化特征和各个诱发电位成分的占比表明,神经元网络对传入刺激的兴奋回响加速,顶叶皮质和海马体中的放电后延,这证明了这些脑结构中信息处理的特殊性。根据其他作者的数据,推测实验动物的电生理参数与一些智障儿童群体之间存在一定的平行关系。

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