Matsumura K, Sawada K, Ishida I, Seki Y, Fukuma S, Kuwabara T, Myojo S, Okita S, Ito Y
Gan To Kagaku Ryoho. 1984 Sep;11(9):1871-4.
5 patients with histologically and/or cytologically confirmed lung cancer were treated with Cis-platinum (CDDP) infused into the bronchial artery (BAI). 2 patients with squamous cell carcinoma disclosed hypervascular type and 3 patients with adenocarcinoma demonstrated avascular or hypovascular type on bronchial arterial angiography. All patients showed more than 20% shrinkage of the tumor shadow on chest X-ray taken 2 weeks after BAI and were evaluated to be radiologically effective by Takeuchi's criteria. One patient with squamous cell carcinoma who underwent lobectomy after BAI with 100 mg of CDDP showed grade III histological effects by Shimosato's criteria. The other patient had superior vena cava syndrome and showed regression of a tumor which occluded the orifice of the right upper and showed lobe after BAI with 100 mg of CDDP. By of contrast, only 1 out of the 3 patients with adenocarcinoma who under went resection showed a grade IIa histological effect after BAI with 50 mg of CDDP. Side effects included mild gastrointestinal toxicity in 1 out of the 5 patients. In conclusion, BAI with CDDP was shown to be sufficiently useful as a chemotherapeutic modality for lung cancer, especially for patients with squamous cell carcinoma, because higher local doses can be delivered without systemic toxicity.
5例经组织学和/或细胞学确诊的肺癌患者接受了经支气管动脉灌注顺铂（CDDP）的治疗。2例鳞状细胞癌患者在支气管动脉造影中显示为高血管型，3例腺癌患者显示为无血管或低血管型。所有患者在支气管动脉灌注术后2周拍摄的胸部X光片上显示肿瘤阴影缩小超过20%，并根据竹内标准评估为放射学有效。1例鳞状细胞癌患者在接受100毫克顺铂支气管动脉灌注术后行肺叶切除术，根据下里标准显示为III级组织学效应。另1例患有上腔静脉综合征的患者在接受100毫克顺铂支气管动脉灌注术后，肿瘤消退，该肿瘤阻塞了右上叶开口。相比之下，3例接受切除术的腺癌患者中只有1例在接受50毫克顺铂支气管动脉灌注术后显示为IIa级组织学效应。副作用包括5例患者中有1例出现轻度胃肠道毒性。总之，顺铂支气管动脉灌注作为肺癌的一种化疗方式被证明是足够有效的，特别是对于鳞状细胞癌患者，因为可以在不产生全身毒性的情况下给予更高的局部剂量。
