Marrs T C, Colgrave H F, Gazzard M, Brown R F
Hum Toxicol. 1984 Aug;3(4):289-308. doi: 10.1177/096032718400300405.
The repeated-dose inhalation toxicity of a smoke containing a mixture of three dyes was tested in female mice, rats and guinea pigs. The green component dye (Solvent Green 3) was retained in the lungs. Particularly in the rats marked collections of alveolar macrophages were found. In the same species several other adverse findings were noted: these included adenocarcinomas of the breast in the high-dose group and a dose-related incidence of biliary hyperplasia. Fatty change was noted in the livers of the test-group mice. A large proportion of the high-dose guinea pigs died during the exposure period, for which reason exposure was stopped early in that group, otherwise the guinea pigs were little affected. However, all test groups of all species showed reductions in growth during the exposure period.
对雌性小鼠、大鼠和豚鼠进行了含有三种染料混合物的烟雾的重复剂量吸入毒性测试。绿色成分染料（溶剂绿3）滞留在肺部。特别是在大鼠中发现了大量肺泡巨噬细胞聚集。在同一物种中还观察到其他一些不良发现：这些包括高剂量组的乳腺腺癌和与剂量相关的胆汁增生发生率。在试验组小鼠的肝脏中发现了脂肪变性。高剂量组的大部分豚鼠在暴露期间死亡，因此该组提前停止了暴露，否则豚鼠受影响较小。然而，所有物种的所有试验组在暴露期间均出现生长减缓。
