Gill T J, Gill T J, Kunz H W, Musto N A, Bardin C W
Biol Reprod. 1984 Oct;31(3):595-603. doi: 10.1095/biolreprod31.3.595.
This study was undertaken to examine further the behavior of the Hre gene and its interaction with the growth and reproduction complex genes (grc) in the (Hre x BN)F2, Hre x (Hre x BN)F1 and (BIL/1 x Hre) F2 crosses. The blaze characteristic of rats carrying the Hre gene was linked to testicular weight but not to the body weight or to the major histocompatibility complex (MHC). The Hre defect was genetically unrelated to the testicular defect caused by the grc. The Hre gene had a variable effect on the testes of the rats in different crosses, and it could be categorized into three distinct stages of progressively greater severity. In the cross in which the parents carried the Hre/+ and grc/grc genes, respectively, there was a decreased litter size, an increased male:female ratio in the offspring and poor reproductive performance when compared to a similar cross in which the Hre/+ gene alone was segregating. There was, however, no effect on the severity of the testicular defect. Thus, the grc can interact with the Hre gene to cause embryonic death, which appears to be selective for females, but not to influence the severity of the testicular defect.
本研究旨在进一步研究Hre基因的行为及其在（Hre×BN）F2、Hre×（Hre×BN）F1和（BIL/1×Hre）F2杂交组合中与生长和生殖复合基因（grc）的相互作用。携带Hre基因的大鼠的白斑特征与睾丸重量相关，但与体重或主要组织相容性复合体（MHC）无关。Hre缺陷与grc引起的睾丸缺陷在遗传上无关。Hre基因对不同杂交组合中大鼠的睾丸有不同影响，可分为三个严重程度逐渐增加的不同阶段。在亲本分别携带Hre/+和grc/grc基因的杂交组合中，与仅分离Hre/+基因的类似杂交组合相比，产仔数减少，后代雌雄比例增加，繁殖性能较差。然而，对睾丸缺陷的严重程度没有影响。因此，grc可与Hre基因相互作用导致胚胎死亡，这似乎对雌性具有选择性，但不影响睾丸缺陷的严重程度。
