Lingwood C, Kunz H W, Gill T J
Biochem J. 1985 Oct 15;231(2):401-5. doi: 10.1042/bj2310401.
The regulation of the activity of testicular germ-cell galactolipid sulphotransferase was investigated in rats homozygous for the grc (growth and reproductive complex) gene. In the adult grc homozygotes, the activity was elevated relative to that in the wild-type animals, and a concomitant deficiency of a developmentally regulated sulphotransferase inhibitor was found. Spermatogenesis in the grc homozygotes is blocked at a stage that correlates temporally with the earliest detection of this inhibitor in the wild-type animal. In addition, there was a similar increase in the specific activity of the kidney galactolipid sulphotransferase in the grc homozygotes. This biochemical abnormality is the first to be associated with a genetically regulated, developmental defect linked to the major histocompatibility complex, and it is related to the pathogenesis of one of the major lesions controlled by the grc.
在纯合grc（生长和生殖复合体）基因的大鼠中，研究了睾丸生殖细胞半乳糖脂磺基转移酶活性的调节。在成年grc纯合子中，该酶活性相对于野生型动物有所升高，并且发现了一种发育调节性磺基转移酶抑制剂的伴随性缺乏。grc纯合子的精子发生在一个阶段被阻断，该阶段在时间上与野生型动物中最早检测到这种抑制剂的时间相关。此外，grc纯合子中肾半乳糖脂磺基转移酶的比活性也有类似的增加。这种生化异常是首次与主要组织相容性复合体相关的遗传调控发育缺陷相关联，并且它与grc控制的主要病变之一的发病机制有关。
