Malashenko A M, Kosarev A V
Genetika. 1984 Aug;20(8):1289-94.
The effect of five chemical mutagens--cyclophosphamide, ethyleneimine, ethylmetanesulfonate, cytozar and captan in bone marrow cells of mouse strains TPS, WR, 101/HY, C57BL/6JY, CBA/LacY was studied. The effect was estimated by a frequency of cells with chromosome damages on preparations made 24 hours after the treatment of mice. The strains differentiate by sensitivity to mutagens and reveal specificity which can not be predicted before the experiment. The data obtained demonstrate that testing mutagenicity of chemical compounds gives more reliable results when using a set of mouse strains.
研究了五种化学诱变剂——环磷酰胺、乙撑亚胺、甲基磺酸乙酯、阿糖胞苷和克菌丹对小鼠品系TPS、WR、101/HY、C57BL/6JY、CBA/LacY骨髓细胞的影响。通过处理小鼠24小时后制备的标本上染色体受损细胞的频率来评估这种影响。这些品系在对诱变剂的敏感性上存在差异，并显示出实验前无法预测的特异性。所获得的数据表明，使用一组小鼠品系来测试化合物的诱变性能得到更可靠的结果。
