Malashenko A M, Vasil'eva S V
Genetika. 1985 Apr;21(4):582-5.
The ability of para-aminobenzoic acid--vitamin (PABA) to influence the sensitivity of mice to alkylating mutagens was studied. PABA had no influence on the cytogenetic effect of thio-TEPA. It was determined that PABA altered the effect of N-ethyl nitrosourea (ENU). The direction of modification depends on animal genotype: pre-treatment with PABA decreases the frequency of chromosome aberrations in bone marrow cells of CBA/LacY and C57BL/JY mice, but significantly increases it in 101/HY mice. The PABA influence on the frequency of gene mutations induced by ENU in melanocytes of mice and revealed by "spot-test" was not determined.
研究了对氨基苯甲酸 - 维生素（PABA）影响小鼠对烷基化诱变剂敏感性的能力。PABA对硫代替派的细胞遗传学效应没有影响。已确定PABA改变了N-亚硝基脲（ENU）的效应。修饰的方向取决于动物基因型：用PABA预处理可降低CBA/LacY和C57BL/JY小鼠骨髓细胞中染色体畸变的频率，但在101/HY小鼠中则显著增加。未确定PABA对ENU诱导的小鼠黑素细胞基因突变频率的影响（通过“斑点试验”揭示）。
