Ito J I, Harrison H R, Alexander E R, Billings L J
J Infect Dis. 1984 Oct;150(4):577-82. doi: 10.1093/infdis/150.4.577.
A human oculogenital strain of Chlamydia trachomatis was instilled intravaginally in the outbred CF-1 mouse to establish cervical infection. The mice were neither hormonally nor immunologically manipulated before inoculation. Duration of chlamydial excretion varied from two to ten days. In the culture-positive animals, IgG and IgM antibody titers were elevated in 38% and 17%, respectively. Neither intracytoplasmic inclusions nor elementary bodies of C. trachomatis were detected in genital tissues. Infection was limited primarily to the cervix and only rarely extended into the uterus. Chlamydial infection could only be established during specific periods of the estrus cycle (metestrus-2, diestrus, and proestrus; P less than .001), stages when leukocytes are present in the vaginal smear. Thus, chlamydial infection of the cervix is cycle-dependent in the mouse. In summary, infection of the cervix of the mouse has been established with a human oculogenital strain of C. trachomatis and may be useful as a model of human chlamydial cervicitis.
将一株沙眼衣原体人眼-生殖道菌株经阴道接种到远交系CF-1小鼠体内，以建立宫颈感染。接种前，未对小鼠进行激素或免疫处理。衣原体排出的持续时间为2至10天。在培养阳性的动物中，IgG和IgM抗体滴度分别升高了38%和17%。在生殖组织中未检测到沙眼衣原体的胞质内包涵体或原体。感染主要局限于宫颈，很少蔓延至子宫。衣原体感染仅在发情周期的特定时期（动情后期-2、动情间期和动情前期；P<0.001）才能建立，即阴道涂片中有白细胞的阶段。因此，小鼠宫颈的衣原体感染是周期依赖性的。总之，已用人沙眼衣原体眼-生殖道菌株建立了小鼠宫颈感染，这可能作为人类衣原体宫颈炎的模型。
