Gilja I, Radej M, Kovacić M, Parazajder J
J Urol. 1984 Nov;132(5):909-11. doi: 10.1016/s0022-5347(17)49941-1.
The results of a clinical study of conservative treatment of women with stress incontinence are presented. A daily dose of 75 mg. imipramine hydrochloride was given for 4 weeks. Special attention was paid to the effects of imipramine on the functional urethral length and maximum urethral closure pressure. A total of 21 women (71 per cent) stated that they were continent after treatment with imipramine, while 9 (29 per cent) did not improve and treatment was stopped. According to our results, imipramine extended the functional urethral length and made it independent of stress factors in women who were continent after treatment with imipramine. In patients with persistent incontinence the functional urethral length was extended significantly but was shortened with stress despite imipramine therapy. We believe that imipramine could be an alternative treatment in selected cases with stress incontinence.
本文介绍了压力性尿失禁女性保守治疗的临床研究结果。给予盐酸丙咪嗪每日剂量75毫克，持续4周。特别关注丙咪嗪对功能性尿道长度和最大尿道闭合压的影响。共有21名女性（71%）表示在接受丙咪嗪治疗后不再尿失禁，而9名（29%）没有改善，治疗停止。根据我们的结果，丙咪嗪延长了功能性尿道长度，并使其在接受丙咪嗪治疗后不再尿失禁的女性中不受压力因素影响。在持续性尿失禁患者中，功能性尿道长度虽显著延长，但尽管接受了丙咪嗪治疗，在压力状态下仍会缩短。我们认为，在某些压力性尿失禁病例中，丙咪嗪可能是一种替代治疗方法。
