Saknyn' A V, Blokhin V A
Vopr Onkol. 1978;24(4):44-8.
The authors conducted observations of 70 nonpedigree white rats, subjected to inhalation, intraperitoneal or intratracheal effect of nickel-containing dusts (feinstein, nickel monoxide) typical for nickel black production. It was found that intraperitoneal injection of feinstein dusts after 6-15 months was followed by the development of sarcomas at the site of injection (in 6 of 39 rats). Following inhalation dusting with feinstein dust in one of 5 cases squamous cell lung carcinoma without keratinization has arisen. Intracheal injection of nickel monoxide dust resulted in the development of squamous cell lung carcinoma without keratinization in one of 26 rats. In control series no tumors were found. The data obtained indicate the blastomogenic effect of dusts of nickel black production and are in keeping with the results of epidemiological studies and dictate the necessity of radical measures of the combat against dust at nickel-production plants.
作者对70只非纯种白鼠进行了观察，使其吸入、腹腔注射或气管内注入镍黑生产过程中典型的含镍粉尘（芬斯坦、一氧化镍）。结果发现，腹腔注射芬斯坦粉尘6至15个月后，注射部位出现肉瘤（39只大鼠中有6只）。5例中1例吸入芬斯坦粉尘后出现了无角化的鳞状细胞肺癌。气管内注入一氧化镍粉尘后，26只大鼠中有1只出现了无角化的鳞状细胞肺癌。对照组未发现肿瘤。所获数据表明镍黑生产粉尘具有致瘤作用，与流行病学研究结果相符，也表明有必要在镍生产工厂采取彻底的防尘措施。
