Martin-Oar J E, Cachofeiro M V, Rodriguez-Puyol D, Hernando L, López-Novoa J M
Nephron. 1984;38(3):188-92. doi: 10.1159/000183306.
The size distribution pattern of circulating rPRL was studied in intact control (C) rats and in three uremic models, namely urine autoinfusion (UA), bilateral ureteral ligation (BUL), and bilateral nephrectomy (BNx). Plasmas were chromatographed by gel filtration in Sephadex G-100. Rat PRL was measured by RIA. The rPRL levels as well as the size distribution pattern of UA were similar to that of C. BUL and BNx showed a similar degree of hyperprolactinemia which corresponded to an increase in little rPRL. The results suggest that acute uremic hyperprolactinemia seems to be the result of accumulation of little rPRL. Acute uremia by itself does not increase rPRL plasma levels nor does it seem to affect the size distribution pattern of circulating rPRL.
在完整对照（C）大鼠以及三种尿毒症模型，即尿液自身输注（UA）、双侧输尿管结扎（BUL）和双侧肾切除（BNx）大鼠中，研究了循环中rPRL的大小分布模式。血浆通过在Sephadex G - 100中进行凝胶过滤色谱分析。通过放射免疫分析法测定大鼠PRL。UA的rPRL水平以及大小分布模式与C组相似。BUL和BNx表现出相似程度的高催乳素血症，这与小rPRL的增加相对应。结果表明，急性尿毒症性高催乳素血症似乎是小rPRL积累的结果。急性尿毒症本身不会增加rPRL血浆水平，也似乎不会影响循环中rPRL的大小分布模式。
