Rodríguez-Puyol D, Martín-Oar J E, Cachofeiro M V, del Pino D, López-Novoa J M, Hernando L
J Clin Endocrinol Metab. 1986 Feb;62(2):352-6. doi: 10.1210/jcem-62-2-352.
Serum PRL levels and its molecular heterogeneity were analyzed, basally and after 500 micrograms TRH given acutely, in four groups of men: normal (C, n = 12), chronic renal failure (CRF, n = 11), hemodialysis (HD, n = 12), and transplant recipients (T, n = 11). The mean basal PRL level was higher in group CRF than in group C and even higher in group HD. The basal hyperprolactinemia was due to increased concentrations of little PRL. The absolute levels of total and little PRL 20 min after TRH were comparable in the four groups. The disappearance index (DI = PRL20-PRL120/PRL20) for total and little PRL was lower in CRF than in C and even lower in HD. A positive correlation was found between the DIs of total and little PRL and creatinine clearance in group CRF. Group T had basal and 20 min serum PRL levels and a pattern of molecular distribution similar to those of group C but total and little PRL DI was lower. These results demonstrate that uremic hyperprolactinemia is due to increases in little PRL without major changes in big and big-big forms of PRL. The reduction of glomerular filtration rate seems to be one of the most important mechanisms responsible for little PRL accumulation.
对四组男性进行了基础状态下以及急性给予500微克促甲状腺激素释放激素（TRH）后血清催乳素（PRL）水平及其分子异质性的分析。这四组分别为：正常组（C组，n = 12）、慢性肾衰竭组（CRF组，n = 11）、血液透析组（HD组，n = 12）以及移植受者组（T组，n = 11）。CRF组的基础PRL平均水平高于C组，HD组则更高。基础高催乳素血症是由于小分子PRL浓度增加所致。TRH给药20分钟后，四组中总PRL和小分子PRL的绝对水平相当。CRF组中总PRL和小分子PRL的消失指数（DI = PRL20 - PRL120/PRL20）低于C组，HD组更低。在CRF组中，总PRL和小分子PRL的消失指数与肌酐清除率之间存在正相关。T组的基础和20分钟血清PRL水平以及分子分布模式与C组相似，但总PRL和小分子PRL的消失指数较低。这些结果表明，尿毒症性高催乳素血症是由于小分子PRL增加，而大分子和大 - 大分子形式的PRL无重大变化。肾小球滤过率降低似乎是小分子PRL蓄积的最重要机制之一。
