Fujimaki H, Ozawa M, Imai T, Kubota K, Watanabe N
Int Arch Allergy Appl Immunol. 1984;75(4):351-6. doi: 10.1159/000233646.
The adjuvant effects of aluminum silicate on IgE and IgG1 antibody production were investigated. BALB/c mice were immunized intraperitoneally with 10 micrograms ovalbumin (OA) adsorbed on 0.2, 2, or 20 mg aluminum silicate. The enhancement of anti-OA IgE antibody production was observed in the mice injected with aluminum silicate and antigen compared with the mice injected with antigen alone. Anti-OA IgE antibody production with 2 and 20 mg aluminum silicate was greater than that with aluminum hydroxide (alum) as an adjuvant. Similar adjuvant effects with 2 mg aluminum silicate or alum were observed in AKR and C57BL/6 mice using 10 micrograms OA, and in BALB/c mice using 2 micrograms DNP-KLH (dinitrophenyl keyhole limpet hemocyanin): IgE antibody production induced by aluminum silicate adjuvant persisted for weeks in these experiments. The enhancement of IgG1 antibody production to OA mixed with aluminum silicate was also demonstrated. However, no difference between aluminum silicate and alum was observed on the IgG1 antibody production.
研究了硅酸铝对IgE和IgG1抗体产生的佐剂效应。用吸附于0.2、2或20mg硅酸铝上的10微克卵清蛋白（OA）对BALB/c小鼠进行腹腔免疫。与仅注射抗原的小鼠相比，在注射了硅酸铝和抗原的小鼠中观察到抗OA IgE抗体产生增强。使用2mg和20mg硅酸铝时抗OA IgE抗体的产生量高于使用氢氧化铝（明矾）作为佐剂时。在使用10微克OA的AKR和C57BL/6小鼠以及使用2微克二硝基苯基钥孔戚血蓝蛋白（DNP-KLH）的BALB/c小鼠中，观察到2mg硅酸铝或明矾具有类似的佐剂效应：在这些实验中，由硅酸铝佐剂诱导的IgE抗体产生持续数周。还证明了与硅酸铝混合的OA的IgG1抗体产生增强。然而，在IgG1抗体产生方面，未观察到硅酸铝和明矾之间存在差异。
