用精神药物长期治疗后大鼠大脑皮层中福斯高林刺激的腺苷酸环化酶活性。
Forskolin-stimulated adenylate cyclase activity in rat cerebral cortex following chronic treatment with psychotropic drugs.
作者信息
Andersen P H, Klysner R, Geisler A
出版信息
Acta Pharmacol Toxicol (Copenh). 1984 Oct;55(4):278-82. doi: 10.1111/j.1600-0773.1984.tb01982.x.
Rats were treated with lithium, imipramine, reserpine, and lithium combined with imipramine or reserpine. Lithium was given in the diet (40 mmol/kg) resulting in a serum-Li+ level of 0.5-0.6 mmol/l. Other drugs were dissolved in 0.9% saline and given intraperitoneally once or twice daily. After 3 weeks of treatment, forskolin-stimulated adenylate cyclase activity was measured in cerebral cortex homogenates. Reserpine did not affect the forskolin stimulation, while both imipramine and lithium caused a decrease in this activity. The combined treatments lithium-imipramine and lithium-reserpine also exhibited a clear decrease in forskolin stimulation, but the effect of concomitant lithium and imipramine treatment did not differ from the effect seen after any of the treatments alone. The unstimulated activity was unaltered by all treatments. The inhibition of lithium and imipramine on the forskolin stimulation indicates an interference of these two drugs with the forskolin-mediated activation of the adenylate cyclase.
将大鼠分为几组，分别用锂盐、丙咪嗪、利血平以及锂盐与丙咪嗪或利血平联合处理。锂盐通过饮食给予（40 mmol/kg），使血清锂离子水平达到0.5 - 0.6 mmol/L。其他药物溶解于0.9%的生理盐水中，每天腹腔注射一次或两次。治疗3周后，在大脑皮层匀浆中测量福斯高林刺激的腺苷酸环化酶活性。利血平不影响福斯高林刺激，而丙咪嗪和锂盐均导致该活性降低。锂盐 - 丙咪嗪和锂盐 - 利血平联合处理也使福斯高林刺激明显降低，但锂盐与丙咪嗪联合治疗的效果与单独使用任何一种治疗后的效果无差异。所有处理均未改变基础活性。锂盐和丙咪嗪对福斯高林刺激的抑制表明这两种药物干扰了福斯高林介导的腺苷酸环化酶激活。
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