Mattsson R, Mattsson A
Dev Comp Immunol. 1984 Fall;8(4):921-9. doi: 10.1016/0145-305x(84)90074-0.
The effects of syngeneic (CBAxCBA) and allogeneic (CBAxC57/B1) pregnancy on immunoglobulin (Ig)-secreting cells in various maternal organs/tissues have been investigated by using the protein A plaque assay. The following organs/tissues were examined: a) spleen, b) cervical nodes, c) inguinal nodes, d) mesenteric nodes, e) para-aortic (uterus-draining) nodes, f) Peyer's patches, and g) bone marrow (femur). The changes observed were similar and of the same magnitude in all pregnant animals, irrespective of the type of mating. At mid-gestation (day 14) a distinct increase in Ig secretors was observed, predominantly in the spleen. At the end of pregnancy (day 20) the para-aortic nodes contained dramatically increased numbers of plaque forming cells. A slight increase in both IgM and IgG-secreting cells was also seen in bone marrow at the very end of pregnancy, while Peyer's patches and the nodes of neck and legs appeared to be unaffected throughout the period of gestation.
利用蛋白A空斑试验研究了同基因（CBAxCBA）和异基因（CBAxC57/B1）妊娠对母体各种器官/组织中免疫球蛋白（Ig）分泌细胞的影响。检查了以下器官/组织：a）脾脏，b）颈淋巴结，c）腹股沟淋巴结，d）肠系膜淋巴结，e）主动脉旁（引流子宫）淋巴结，f）派伊尔结，g）骨髓（股骨）。在所有妊娠动物中观察到的变化相似且程度相同，与交配类型无关。在妊娠中期（第14天），观察到Ig分泌细胞明显增加，主要在脾脏中。在妊娠末期（第20天），主动脉旁淋巴结中形成空斑细胞的数量急剧增加。在妊娠末期，骨髓中分泌IgM和IgG的细胞也略有增加，而派伊尔结以及颈部和腿部的淋巴结在整个妊娠期似乎未受影响。
