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吲哚美辛对雌二醇诱导的精囊增殖反应的抑制作用。

Indomethacin suppression of the estradiol-induced proliferative response of the seminal vesicles.

作者信息

Lysoń K

出版信息

Exp Clin Endocrinol. 1984 Oct;84(2):223-7.

PMID:6543185
Abstract

Effects of indomethacin (1.25 mg/kg of body weight and 1.25 mg/rat) on estradiol-induced (250 micrograms/rat and 25 micrograms/rat) mitotic activity of the seminal vesicles and the ventral prostate in rats were examined. The obtained results show clearly that indomethacin restrains the seminal vesicles proliferative reaction induced by estradiol, whereas the ventral prostate is not sensitive to estradiol, and indomethacin does not affect its mitotic activity. These results suggest that prostaglandins are involved in the mitogenic effect of estradiol on the seminal vesicles.

摘要

研究了吲哚美辛(1.25毫克/千克体重和1.25毫克/只大鼠)对雌二醇诱导(250微克/只大鼠和25微克/只大鼠)的大鼠精囊和腹侧前列腺有丝分裂活性的影响。所获结果清楚地表明,吲哚美辛抑制雌二醇诱导的精囊增殖反应,而腹侧前列腺对雌二醇不敏感,吲哚美辛不影响其有丝分裂活性。这些结果提示,前列腺素参与了雌二醇对精囊的促有丝分裂作用。

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