Lysoń K, Pawlikowski M
J Androl. 1983 Mar-Apr;4(2):167-70. doi: 10.1002/j.1939-4640.1983.tb00745.x.
Effects of indomethacin (1.25 mg/kg) and aspirin (20 mg/kg) on testosterone-induced (0.25 mg/rat), and of indomethacin on dihydrotestosterone-induced (0.25 mg/rat) mitotic activity of the seminal vesicles and the ventral prostate in rats were examined. The results demonstrate that the seminal vesicles' proliferative reaction induced by testosterone was suppressed by treatment with indomethacin and aspirin; whereas, in the ventral prostate, the mitogenic effect of testosterone was not blocked by either of these inhibitors of prostaglandin synthesis. Cellular proliferation induced by dihydrotestosterone was not inhibited by indomethacin in either the seminal vesicles or the ventral prostate. These results suggest the existence of different mechanisms of proliferative reactions of the seminal vesicles and the ventral prostate to testosterone. The results further suggest an involvement of prostaglandins in the mitogenic effect of testosterone on the seminal vesicles.
研究了吲哚美辛（1.25毫克/千克）和阿司匹林（20毫克/千克）对睾酮诱导（0.25毫克/大鼠）的大鼠精囊和腹侧前列腺有丝分裂活性的影响，以及吲哚美辛对双氢睾酮诱导（0.25毫克/大鼠）的大鼠精囊和腹侧前列腺有丝分裂活性的影响。结果表明，用吲哚美辛和阿司匹林处理可抑制睾酮诱导的精囊增殖反应；然而，在腹侧前列腺中，睾酮的促有丝分裂作用并未被这两种前列腺素合成抑制剂所阻断。双氢睾酮诱导的细胞增殖在精囊或腹侧前列腺中均未被吲哚美辛抑制。这些结果提示精囊和腹侧前列腺对睾酮的增殖反应存在不同机制。结果还进一步提示前列腺素参与了睾酮对精囊的促有丝分裂作用。
