Yew F H, Chang L M
J Cell Sci. 1984 Dec;72:213-26. doi: 10.1242/jcs.72.1.213.
The effect of ultraviolet radiation on a cell line established from the warm water fish Tilapia has been assessed by measuring the rate of DNA synthesis, excision repair, post-replication repair and cell survival. The cells tolerate ultraviolet radiation better than mammalian cells with respect to DNA synthesis, post-replication repair and cell survival. They are also efficient in excision repair, which in other fish cell lines has been found to be at a low level or absent. Their response to the inhibitors hydroxyurea and 1-beta-D-arabinofuranosylcytosine is less sensitive than that of other cell lines, yet the cells seem to have very small pools of DNA precursor.
通过测量DNA合成速率、切除修复、复制后修复和细胞存活率，评估了紫外线辐射对从温水鱼罗非鱼建立的细胞系的影响。就DNA合成、复制后修复和细胞存活而言，这些细胞比哺乳动物细胞更能耐受紫外线辐射。它们在切除修复方面也很有效，而在其他鱼类细胞系中，切除修复水平较低或不存在。它们对抑制剂羟基脲和1-β-D-阿拉伯呋喃糖基胞嘧啶的反应比其他细胞系不那么敏感，但这些细胞的DNA前体池似乎非常小。
