Rockman G E, Glavin G B
Alcohol. 1984 Jul-Aug;1(4):293-5. doi: 10.1016/0741-8329(84)90051-x.
Rats were screened in an alcohol-water free-choice paradigm and divided into low-ethanol preferring (1.5-2.5 g/kg/day), medium-ethanol-preferring (2.5-4.5 g/kg/day) and high-ethanol-preferring (4.5-6.0 g/kg/day) groups. In addition, a non-ethanol-exposed group was included. Each of these groups was again subdivided with half the animals in a group being food deprived for 16 hr, and the other half having ad lib access to food. All rats were then subjected to restraint in the supine position in a cold (4-6 degrees C) environment for 3 hr. Significant differences in ulcer incidence and severity (cumulative length of the ulcers expressed in millimeters) occurred, suggesting that higher intake of alcohol is associated with greater ulcer severity. This pattern occurred for both food-deprived and non-deprived animals.
大鼠在酒精-水自由选择范式下进行筛选，并分为低乙醇偏好组（1.5 - 2.5克/千克/天）、中乙醇偏好组（2.5 - 4.5克/千克/天）和高乙醇偏好组（4.5 - 6.0克/千克/天）。此外，还设置了一个未接触乙醇的组。每组动物又被分为两组，每组中一半动物禁食16小时，另一半动物可自由获取食物。然后将所有大鼠在寒冷（4 - 6摄氏度）环境中仰卧位约束3小时。溃疡发生率和严重程度（溃疡累积长度以毫米表示）出现了显著差异，表明较高的酒精摄入量与更严重的溃疡有关。这种模式在禁食和未禁食的动物中均出现。
