Rockman G E, Glavin G B
Pharmacol Biochem Behav. 1986 Apr;24(4):869-73. doi: 10.1016/0091-3057(86)90428-4.
The present study was designed to investigate the relationship between activity stress, alcohol consumption and ulcer proliferation. Ethanol consuming rats were initially divided into low, medium or high ethanol preferring groups on the basis of daily ethanol intake (g/kg/day). Following a habituation period in activity cages, animals were fed for 1 hr per day. Access to both water and ethanol remained ad lib. Yoked control home cage animals were fed the same amount of food consumed by their wheel-housed partners. This procedure continued until wheel-housed animals died, at which time they and their yoked home cage control partners were examined for ulcers. Results indicated that in contrast to the yoked controls, only the high ethanol-preferring rats reduced their ethanol consumption. Although no differences were apparent in ulcer frequency (mean number of ulcers per rat) or severity (mean cumulative ulcer length in millimeters), animals exposed to ethanol had a lower ulcer incidence (number of rats per group developing ulcers) and mortality rate than non-ethanol exposed animals.
本研究旨在调查活动应激、酒精消费与溃疡增殖之间的关系。最初，根据每日乙醇摄入量（克/千克/天）将饮用乙醇的大鼠分为低、中、高乙醇偏好组。在活动笼中经过适应期后，动物每天喂食1小时。水和乙醇的供应均为随意摄取。配对的对照笼养动物喂食与其活动笼同伴消耗的相同量的食物。这个过程一直持续到活动笼中的动物死亡，此时对它们及其配对的笼养对照同伴进行溃疡检查。结果表明，与配对对照相比，只有高乙醇偏好的大鼠减少了乙醇消耗。虽然在溃疡频率（每只大鼠的平均溃疡数）或严重程度（以毫米为单位的平均累积溃疡长度）上没有明显差异，但与未接触乙醇的动物相比，接触乙醇的动物溃疡发生率（每组发生溃疡的大鼠数量）和死亡率较低。
