Rockman G E, Hall A M, Markert L, Glavin G B, Pare W P
Department of Psychology, University of Winnipeg, Manitoba, Canada.
Alcohol. 1987 Sep-Oct;4(5):391-4. doi: 10.1016/0741-8329(87)90072-3.
Rats screened for voluntary ethanol intake (high, medium, and low ethanol-preferring rats and non-ethanol-exposed controls) were given acute immobilization stress either immediately following the ethanol screening procedure, or after a 20 day period without access to ethanol. Among animals examined for stress responses immediately after ethanol screening, it was observed that water-only control rats developed significantly less frequent and less severe gastric stress ulcers than rats in all ethanol-exposed groups. This result suggests that ethanol, stress and routine handling may have contributed to ulcer formation in these animals. In contrast, among rats tested for stress responses after 20 days without ethanol, it was observed that the high ethanol-preferring animals showed less severe stress ulcers. These results indicate that among high ethanol-consuming animals, the presence of ethanol enhances ulcer severity, while prior experience with ethanol consumption does not appear to predispose rats to exacerbated stress gastric pathology.
对自愿摄入乙醇的大鼠（高、中、低乙醇偏好大鼠以及未接触乙醇的对照组）在乙醇筛选程序后立即给予急性固定应激，或者在20天不接触乙醇后给予该应激。在乙醇筛选后立即检查应激反应的动物中，观察到仅饮水的对照大鼠比所有接触乙醇组的大鼠出现的胃应激性溃疡频率明显更低、严重程度也更低。这一结果表明，乙醇、应激和常规处理可能促成了这些动物溃疡的形成。相比之下，在20天不接触乙醇后测试应激反应的大鼠中，观察到高乙醇偏好动物的应激性溃疡不那么严重。这些结果表明，在高乙醇消耗动物中，乙醇的存在会加重溃疡严重程度，而先前的乙醇消费经历似乎不会使大鼠更容易出现应激性胃部病变加剧的情况。
