Lee A E, Pang L S, Miller K, Rogers L A
Clin Exp Metastasis. 1984 Jul-Sep;2(3):191-8. doi: 10.1007/BF00132925.
BR6 mouse mammary tumours were maintained by serial s.c. transplantation into female or castrated male syngeneic hosts. The tumours could be broadly classified according to their structure, and usually remained stable through many passages. Occasionally, sarcomatous changes were seen (64 out of 800 cases). Pulmonary metastases were found in 5 per cent of mice bearing transplants of well-differentiated acinar tumours, in 34 per cent with tumours of the acinar/ductal type, and in 97 per cent with poorly differentiated tumours. There was a similar correlation between lymph node metastases and degree of primary tumour differentiation, the incidences being 0, 0.5 and 22 per cent respectively. Sarcomatous changes were associated with a reduced incidence of metastasis. Local invasion of muscle or peritoneum occurred in 32 per cent of mice with well-differentiated tumours, and in 59 per cent with less differentiated tumours. Selection for increased metastatic potential was not achieved by transplantation of lung nodules to a subcutaneous site.
BR6小鼠乳腺肿瘤通过连续皮下移植到雌性或去势雄性同基因宿主中得以维持。这些肿瘤可根据其结构大致分类，并且在许多传代过程中通常保持稳定。偶尔会出现肉瘤样变化（800例中有64例）。在携带高分化腺泡肿瘤移植瘤的小鼠中，5%出现肺转移；在腺泡/导管型肿瘤小鼠中，34%出现肺转移；在低分化肿瘤小鼠中，97%出现肺转移。淋巴结转移与原发肿瘤分化程度之间也存在类似的相关性，发生率分别为0、0.5%和22%。肉瘤样变化与转移发生率降低有关。高分化肿瘤小鼠中有32%发生肌肉或腹膜局部侵犯，低分化肿瘤小鼠中有59%发生肌肉或腹膜局部侵犯。将肺结节移植到皮下部位并不能实现对转移潜能增加的选择。
