Liotti F S, Menghini A R, Guerrieri P, Armellini R
Institute of General Biology, University of Perugia, Italy.
Oncology. 1988;45(6):453-7. doi: 10.1159/000226665.
The present research demonstrates that cells from an ascites tumour (ATP C+) multiply more actively in the peritoneum of male mice, provided they are maintained alive in this environment for long periods of time by weekly transplants in animals of the same sex. Solid tumours obtained by inoculating ATP C+ cells, removed from the peritoneum of male mice, into the subcutaneous dorsal region of castrated male mice, grew more rapidly than those obtained by inoculating the same cells removed from the peritoneum of female mice, always provided that the cells had been passaged at length in animals of the same sex. Cytogenetical studies of these two cell subpopulations revealed that cells reproduced for 2 years in males had a less stabile karyotype and a greater incidence of acrocentric associations.
目前的研究表明，来自腹水肿瘤（ATP C+）的细胞在雄性小鼠的腹膜中繁殖更为活跃，前提是通过每周在同性动物中进行移植，使其在这种环境中长时间存活。将从雄性小鼠腹膜中取出的ATP C+细胞接种到去势雄性小鼠的背部皮下区域所获得的实体瘤，比接种从雌性小鼠腹膜中取出的相同细胞所获得的实体瘤生长得更快，前提是这些细胞已在同性动物中传代足够长的时间。对这两个细胞亚群的细胞遗传学研究表明，在雄性中繁殖2年的细胞具有较不稳定的核型和较高的近端着丝粒联合发生率。
