Arimoto T, Irie G, Tsujii H, Ito S, Mizoe J, Kamada T, Miyamoto M, Sirato H
Radiat Med. 1984 Jul-Sep;2(3):205-9.
In this paper a so-called "supralethal dose phenomenon" is reported. Two groups of patients, all of whom were carrying proved squamous cell carcinoma of the same clinical stage in their maxillary sinuses, were compared after radiotherapy in our department. The radiotherapies applied to the two groups were very similar in terms of fraction number, treatment period, dose distribution and immobilization technique, but differed in dose, i.e., 5,500 cGy for one group of 9 patients and 5,750 cGy for the other group of 20 patients. The five-year survival rates of the two groups were 8/9 and 10/20, respectively, and the difference was statistically significant (p less than 0.05). All patients were observed for at least five years. Except for tumor stage, the status of the patients in the two groups, including primary site of the tumor in the sinus, patients' age and cause of death for the failed cases, are also discussed in detail.
本文报道了一种所谓的“超致死剂量现象”。在我们科室，对两组上颌窦鳞状细胞癌临床分期相同且经证实的患者进行了放疗后比较。两组所采用的放疗在分次次数、治疗周期、剂量分布和固定技术方面非常相似，但剂量不同，即一组9例患者接受5500厘戈瑞，另一组20例患者接受5750厘戈瑞。两组的五年生存率分别为8/9和10/20，差异具有统计学意义（p小于0.05）。所有患者均观察了至少五年。除肿瘤分期外，还详细讨论了两组患者的情况，包括鼻窦内肿瘤的原发部位、患者年龄以及失败病例的死亡原因。
