与反应性抑郁症相比，内源性抑郁症患者对可乐定的生长激素反应。

The GH response to clonidine in endogenous as compared with reactive depression.

作者信息

Checkley S A, Glass I B, Thompson C, Corn T, Robinson P

出版信息

Psychol Med. 1984 Nov;14(4):773-7. doi: 10.1017/s0033291700019747.

DOI:10.1017/s0033291700019747

Abstract

The growth hormone (GH) response to clonidine was measured in 10 patients meeting standardized criteria for 'endogenous' depression and in 10 patients individually matched for age and sex but meeting the corresponding criteria for 'reactive' depression. In a paired comparison of patients with reactive and endogenous depression (matched for age and sex), the GH response to clonidine was less in the endogenous member of the pair in 8 out of 10 cases. These findings are interpreted as evidence of a defect at alpha 2 adrenoceptors in neuroendocrine systems in endogenous as compared with reactive depression.

摘要

对10名符合“内源性”抑郁症标准化标准的患者以及10名年龄和性别与之匹配但符合“反应性”抑郁症相应标准的患者，测量了他们对可乐定的生长激素（GH）反应。在反应性抑郁症和内源性抑郁症患者（年龄和性别匹配）的配对比较中，10例中有8例，内源性抑郁症患者对可乐定的GH反应较低。这些发现被解释为与反应性抑郁症相比，内源性抑郁症患者神经内分泌系统中α2肾上腺素能受体存在缺陷的证据。