Goraca A, Traczyk W Z, Konarzewska A
Acta Physiol Pol. 1984 Sep-Dec;35(5-6):454-9.
Studies were carried out on the right auricle of the right atrium of two-day-old rats placed in a special chamber perfused with Ringer-Locke solution at room temperature. The contractions rate of the auricle was counted with the use of a stereomicroscope. The following amino acids dissolved in Ringer-Locke solution were tested: glycine, glutamic acid, serine, alanine, aspartic acid, gamma aminobutyric acid, leucine, and peptides: vasopressin and oxytocin. Glutamic acid in a concentration of 10(-1) mol/l induced a decrease in auricle contraction rate by 25%. Alanine in concentration 10(-2) mol/l induced a decrease by 22%. Leucine in concentration 10(-2) mol/l induced a decrease by 16% and in concentration ten times higher a decrease by 28%. The other tested amino acids, vasopressin and oxytocin in concentration used had no influence on the rate of contraction frequency of the isolated auricle.
实验在置于特殊腔室的两日龄大鼠右心房右心耳上进行，该腔室在室温下用林格 - 洛克溶液灌注。使用体视显微镜计算心耳的收缩率。测试了溶解于林格 - 洛克溶液中的以下氨基酸：甘氨酸、谷氨酸、丝氨酸、丙氨酸、天冬氨酸、γ - 氨基丁酸、亮氨酸，以及肽类：血管加压素和催产素。浓度为10(-1) mol/l的谷氨酸使心耳收缩率降低25%。浓度为10(-2) mol/l的丙氨酸使收缩率降低22%。浓度为10(-2) mol/l的亮氨酸使收缩率降低16%，浓度高十倍时使收缩率降低28%。其他测试的氨基酸、所用浓度的血管加压素和催产素对分离的心耳收缩频率无影响。
