Goraca A, Traczyk W Z
Department of Physiology, School of Medicine, Poland.
Acta Physiol Pol. 1990 Nov-Dec;41(7):54-64.
Investigations have shown the presence of a cardiodepressant factor in the fluid incubating the posterior pituitary lobe "in situ", which decreased contraction frequency of the isolated heart auricle (Acta Physiol. Pol., 1984, 35: 460-468). The influence on the spontaneous contraction frequency of the isolated heart auricle of the following synthetic neuropeptides was determined: substance P, leu-enkephalin, met-enkephalin, angiotensin II, arg-vasopressin, oxytocin, delta sleep-inducing peptide and atrial natriuretic factor. It was found that the investigated neuropeptides had no effect on the contraction frequency of the isolated auricle of the heart right atrium of two-day-old rat in a concentration from 2.1 x 10(-7) to 1 x 10(-3) mol/l in the bathing medium and it was concluded that their biological properties differ from the cardiodepressant factor.
研究表明，在“原位”孵育垂体后叶的液体中存在一种心脏抑制因子，它会降低离体心脏心房的收缩频率（《波兰生理学报》，1984年，35卷：460 - 468页）。测定了以下合成神经肽对离体心脏心房自发收缩频率的影响：P物质、亮氨酸脑啡肽、甲硫氨酸脑啡肽、血管紧张素II、精氨酸加压素、催产素、δ睡眠诱导肽和心钠素。结果发现，在所研究的神经肽中，当它们在灌流液中的浓度为2.1×10⁻⁷至1×10⁻³mol/L时，对两日龄大鼠离体右心房的收缩频率没有影响，由此得出结论，它们的生物学特性与心脏抑制因子不同。
