Ackerman N B, Hechmer P A
Am J Surg. 1980 Nov;140(5):625-31. doi: 10.1016/0002-9610(80)90044-6.
The effects of epinephrine on the vascular perfusion of solitary Walker tumors implanted in the liver were studied in Sprague-Dawley rats. Colored silicone rubber (Microfil) solutions were injected into the arterial and portal circulations in each animal, and specimens were studied under a stereomicroscope. Internal vascular volume was calculated on the basis of the interference of light passing through the central portions of the tumors by Microfil-filled vessels. Intraarterial epinephrine, in doses of 100 or 10 micrograms, markedly increased vascular perfusion in the encircling plexus and the internal tumor circulation compared with control animals. Internal vascular volume was significantly increased from 9.4 percent in controls to 22.5 percent in epinephrine-treated animals. Increased perfusion was also seen when epinephrine was administered through the portal system, and in larger tumors after intraarterial administration. Internal tumor vessels were capillary-like in appearance.
在斯普拉格-道利大鼠中研究了肾上腺素对植入肝脏的单个沃克肿瘤血管灌注的影响。向每只动物的动脉和门静脉循环中注射彩色硅橡胶（Microfil）溶液，并在体视显微镜下研究标本。根据充满Microfil的血管对穿过肿瘤中心部分的光的干扰来计算内部血管体积。与对照动物相比，剂量为100或10微克的动脉内肾上腺素显著增加了环绕丛和肿瘤内部循环的血管灌注。内部血管体积从对照组的9.4%显著增加到肾上腺素治疗组动物的22.5%。当通过门静脉系统给予肾上腺素时，以及在动脉内给药后较大的肿瘤中也观察到灌注增加。肿瘤内部血管外观呈毛细血管样。
