Toki H, Okabe K, Ishikawa M, Fujii M, Kimura Y
Gan To Kagaku Ryoho. 1984 Feb;11(2):260-4.
We have retrospectively studied the problems concerning duration of maintenance therapy and chemotherapy regimens for non-Hodgkin's lymphoma treated at Shikoku Cancer Center Hospital. Four out of 15 complete remission cases had been in complete remission more than 3 years. Maintenance chemotherapy consists of CHOP protocol administering every 4 weeks and the median maintenance duration was 14 months with a median cycle of 14. Thereafter, patients have been followed up without receiving any therapy. The prospective study on maintenance therapy should be designed considering conditions such as 1) sufficient drug doses for cytocidal effects, 2) shorter maintenance period as possible, and 3) minimal side effects and complications to be expected.
我们回顾性研究了四国癌症中心医院治疗的非霍奇金淋巴瘤维持治疗的持续时间和化疗方案相关问题。15例完全缓解病例中有4例已完全缓解超过3年。维持化疗采用每4周一次的CHOP方案，中位维持时间为14个月，中位周期为14个。此后，对患者进行随访，未接受任何治疗。应考虑以下条件设计维持治疗的前瞻性研究：1）足够的杀细胞药物剂量；2）尽可能缩短维持期；3）预期的副作用和并发症最小。
