Liebowitz D, Massaro G D, Massaro D
J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):564-7. doi: 10.1152/jappl.1984.56.3.564.
We examined the effect of adrenalectomy (ADX) on aspects of the surfactant system of adult rats. Five days after bilateral ADX, ADX rats had about 20% less disaturated phosphatidylcholine (DSPC) in lung lavage returns (airway DSPC) than sham-operated rats, but the amount of tissue DSPC was not different between the groups; airway DSPC formed 12.8 +/- 0.5% of total DSPC (airway + tissue) in ADX and 15.9 +/- 0.7% in sham-ADX rats. An ultrastructural morphometric analysis of alveolar type 2 cells did not reveal an effect of ADX on lamellar body volume density or surface-to-volume ratio. ADX rats had heavier lungs (not as a result of edema) than sham-ADX rats. Treatment of ADX rats with hydrocortisone returned the amount of DSPC toward normal and eliminated the increase of lung weight. ADX did not alter the recoil of saline-filled lungs but did slightly increase the recoil of air-filled lungs. We conclude that corticosteroid hormones influence the in vivo functioning of the surfactant system of adult rats, but this effect seems to be slight.
我们研究了肾上腺切除术（ADX）对成年大鼠表面活性剂系统各方面的影响。双侧ADX术后5天，ADX大鼠肺灌洗回收液（气道二棕榈酰磷脂酰胆碱，DSPC）中的二饱和磷脂酰胆碱比假手术大鼠少约20%，但两组之间组织DSPC的量没有差异；ADX大鼠气道DSPC占总DSPC（气道+组织）的12.8±0.5%，假手术ADX大鼠为15.9±0.7%。对Ⅱ型肺泡细胞进行超微结构形态计量分析未发现ADX对板层小体体积密度或表面积与体积比有影响。ADX大鼠的肺比假手术ADX大鼠重（并非因水肿所致）。用氢化可的松治疗ADX大鼠可使DSPC量恢复正常并消除肺重量增加。ADX未改变生理盐水填充肺的回缩力，但略微增加了空气填充肺的回缩力。我们得出结论，皮质类固醇激素会影响成年大鼠表面活性剂系统的体内功能，但这种影响似乎很轻微。
