D'Amours R, Clerch L, Massaro D
J Appl Physiol Respir Environ Exerc Physiol. 1983 Nov;55(5):1413-7. doi: 10.1152/jappl.1983.55.5.1413.
We sought to determine if fasting (80% reduction of food intake for 72 h) diminishes airway or tissue disaturated phosphatidylcholine (DSPC) relative to alveolar surface area, or alters the lung response to overventilation. The lungs of fasted rats were lighter, but the size and recoil of saline-filled lungs, and the alveolar surface area of lungs fixed in glutaraldehyde, were the same in fed and fasted rats. In their airways fed rats had 0.32 +/- 0.01 microgram DSPC/cm2 of alveolar surface; fasted rats had 0.28 +/- 0.02 microgram DSPC/cm2 (P less than 0.05) (surface area determined at 20 cmH2O transpulmonary pressure). Fasted rats had 13% less tissue DSPC/cm2 alveolar surface than fed rats (P less than 0.01). After 1 h of mechanically produced overventilation the unequal amounts of airway, but not tissue, DSPC were eliminated and pulmonary compliance was similar in both groups. We conclude food reduction decreases the quantity of airway and tissue DSPC/cm2 of alveolar surface but does not increase lung recoil of spontaneously breathing rats (Gail, Massaro, and Massaro, J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 42: 88-92, 1977) or overventilated rats.
我们试图确定禁食（72小时食物摄入量减少80%）是否会使气道或组织中的不饱和磷脂酰胆碱（DSPC）相对于肺泡表面积减少，或者是否会改变肺部对过度通气的反应。禁食大鼠的肺重量较轻，但喂食和禁食大鼠中，充满生理盐水的肺的大小和弹性，以及用戊二醛固定的肺的肺泡表面积是相同的。在气道中，喂食大鼠每平方厘米肺泡表面积含0.32±0.01微克DSPC；禁食大鼠为0.28±0.02微克DSPC（P<0.05）（在20厘米水柱跨肺压下测定表面积）。禁食大鼠每平方厘米肺泡表面积的组织DSPC比喂食大鼠少13%（P<0.01）。在机械性过度通气1小时后，两组气道中不等量的DSPC（而非组织中的）被消除，且两组的肺顺应性相似。我们得出结论，食物摄入量减少会降低气道和组织中每平方厘米肺泡表面积的DSPC量，但不会增加自主呼吸大鼠（盖尔、马萨罗和马萨罗，《应用生理学杂志：呼吸、环境与运动生理学》42:88 - 92,1977）或过度通气大鼠的肺弹性回缩力。
