从生二素链霉菌变种（即抗生素辅酶A的来源）中分离新抗生素辅酶A。

Isolation of neocopiamycin A from Streptomyces hygroscopicus var. crystallogenes, the copiamycin source.

作者信息

Arai T, Uno J, Horimi I, Fukushima K

出版信息

J Antibiot (Tokyo). 1984 Feb;37(2):103-9. doi: 10.7164/antibiotics.37.103.

DOI:10.7164/antibiotics.37.103

Abstract

Fermentation of Streptomyces hygroscopicus var. crystallogenes, the copiamycin source, yielded several minor components with antifungal activity. One of these minor components, neocopiamycin A, was isolated and characterized. The structure of neocopiamycin A was determined as N-demethylcopiamycin on the basis of spectroscopic evidence. The antibiotic was found to be more active against Gram-positive bacteria and fungi but less toxic than copiamycin.

摘要

产去甲万古霉素的吸水链霉菌变种的发酵产生了几种具有抗真菌活性的次要成分。其中一种次要成分，新去甲万古霉素A，被分离并进行了表征。基于光谱证据，新去甲万古霉素A的结构被确定为N-去甲基去甲万古霉素。发现该抗生素对革兰氏阳性菌和真菌更具活性，但毒性比去甲万古霉素小。