Weismann K, Mikkelsen H I
Arch Dermatol Res. 1980;269(1):105-7. doi: 10.1007/BF00404465.
The influence of various zinc concentrations on the osmotic resistance of erythrocytes was studied in six normal adults. Sodium chloride solutions ranging from 0.1% to 0.7% were prepared, each containing 0 microgram % zinc, 50 microgram % zinc, 100 microgram % zinc, 500 microgram %, and 1000 microgram % zinc. Heparin-stabilized venous blood was added to the various solutions at 25 degrees C, and the degree of haemolysis (erythrolysis) after 1 h was determined by measurement of the absorbance at 540 nm. Neither the absence, nor the presence of relatively high zinc concentrations were found to influence the degree of haemolysis. The results indicate that haemolytic anaemia which was observed in zinc-deficient patients is not due to a zinc-dependent change in the osmotic resistance of erythrocytes.
在六名正常成年人中研究了不同锌浓度对红细胞渗透压抗性的影响。制备了浓度范围为0.1%至0.7%的氯化钠溶液，每种溶液分别含有0微克%锌、50微克%锌、100微克%锌、500微克%锌和1000微克%锌。在25摄氏度下将肝素化的静脉血添加到各种溶液中，并通过测量540nm处的吸光度来确定1小时后的溶血程度（红细胞溶解）。结果发现，无论是缺乏锌还是存在相对高浓度的锌，均未影响溶血程度。这些结果表明，在缺锌患者中观察到的溶血性贫血并非由于红细胞渗透压抗性的锌依赖性变化所致。
