Spampinato S, Candeletti S, Cavicchini E, Romualdi P, Speroni E, Ferri S
Neurosci Lett. 1984 Mar 23;45(2):135-9. doi: 10.1016/0304-3940(84)90088-0.
Salmon calcitonin injected intrathecally in unanesthetized rats produced long-lasting, dose-dependent elevations of nociceptive threshold as measured in the hot plate test. This antinociceptive action was nonopiate in nature as it was uninfluenced by the narcotic antagonists naloxone and MR 1452; moreover, the peptide was still able to raise the nociceptive threshold in morphine-tolerant rats. It is suggested that the spinal cord may represent one of the sites of action for calcitonin-induced antinociception.
在未麻醉大鼠中鞘内注射鲑鱼降钙素，通过热板试验测量发现，其能产生持久的、剂量依赖性的伤害性感受阈值升高。这种抗伤害感受作用本质上是非阿片类的，因为它不受麻醉拮抗剂纳洛酮和MR 1452的影响；此外，该肽在吗啡耐受的大鼠中仍能提高伤害性感受阈值。有人提出，脊髓可能是降钙素诱导抗伤害感受作用的作用部位之一。
