Maeda Y, Yamada K, Hasegawa T, Iyo M, Fukui S, Nabeshima T
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
J Neural Transm Gen Sect. 1994;96(2):125-33. doi: 10.1007/BF01277934.
We have examined the effects of salmon calcitonin (SCT), injected into the cerebral ventricle (i.c.v.), on the tail-biting and scratching behavior induced by the intrathecal injection of different types of nociceptive agents, i.e., substance P, N-methyl-D-aspartate (NMDA), kainate (KA), and quisqualate (Quis). Tail-biting and scratching behavior induced by the 4 substances was significantly inhibited by SCT (i.c.v.) in the same manner: the dose-response curves were U-shaped, and the most effective dose was 0.1 IU/mouse in all cases. SCT did not, however, completely inhibit tail-biting and scratching behavior. At its most effective dose, the percent inhibition of substance P-, NMDA-, KA- and Quis-induced behavior were 77.9%, 40.2%, 49.4%, and 52.9%, respectively. These results suggest that SCT has the inhibitory effects of substance P- and glutamate receptor agonists-induced nociceptive response in vivo.
我们研究了向脑室注射鲑鱼降钙素（SCT）对鞘内注射不同类型伤害性刺激剂（即P物质、N-甲基-D-天冬氨酸（NMDA）、海藻酸（KA）和quisqualate（Quis））所诱导的咬尾和抓挠行为的影响。SCT（脑室注射）以相同方式显著抑制了这4种物质所诱导的咬尾和抓挠行为：剂量-反应曲线呈U形，且在所有情况下最有效剂量均为0.1 IU/只小鼠。然而，SCT并未完全抑制咬尾和抓挠行为。在其最有效剂量下，对P物质、NMDA、KA和Quis诱导行为的抑制百分比分别为77.9%、40.2%、49.4%和52.9%。这些结果表明，SCT对体内P物质和谷氨酸受体激动剂诱导的伤害性反应具有抑制作用。
