Cisło M, Wawrzkiewicz M, Rzucidlo Z, Kornafel J, Marczewski A, Blok K
Zentralbl Allg Pathol. 1984;129(1):17-9.
Two cases of endodermal sinus tumor (EST) are described in a 19-year-old girl and a 50-year-old menopausal women, respectively. Exstirpation uteri totalis cum adnexis was carried out in both cases. According to the FIGO the tumors were classified as Ic. The histologic diagnosis of EST was based on the presence of elements such as extraembryonic mesoderm, yolk sac mesoderm, vascular structures with Schiller-Duval bodies, PAS-positive globules in Duval sinus spaces. In the first case, where the proposed chemotherapy was refused, the patient died 4 months later with symptoms of abdominal metastases. In the other case, chemotherapy was applied according to the VAC program. At 13 months of the treatment a relaparotomy was made and the lymphatic nodes taken showed no metastases. Three months later, the tumor relapsed and the patient died at 22 months of the therapy. In the light of their observations and literature data the authors recommended a radical surgical intervention combined with intense polychemotherapy as the only effective approach to the problem.
分别描述了一名19岁女孩和一名50岁绝经后女性的两例内胚窦瘤（EST）病例。两例均行全子宫及附件切除术。根据国际妇产科联盟（FIGO）标准，肿瘤分类为Ic期。EST的组织学诊断依据是存在诸如胚外中胚层、卵黄囊胚层、带有席勒-杜瓦尔体的血管结构、杜瓦尔窦间隙中PAS阳性小球等成分。第一例中，患者拒绝了提议的化疗，4个月后死于腹部转移症状。另一例则按照VAC方案进行化疗。治疗13个月时进行了再次剖腹手术，切除的淋巴结未显示转移。3个月后，肿瘤复发，患者在治疗22个月时死亡。根据他们的观察和文献数据，作者建议根治性手术干预联合强化多药化疗是解决该问题的唯一有效方法。
