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Isolation and characterization of a novel disialoganglioside from bovine adrenal medulla.

作者信息

Ariga T, Sekine M, Yu R K, Miyatake T

出版信息

Arch Biochem Biophys. 1984 Jul;232(1):305-9. doi: 10.1016/0003-9861(84)90546-0.

DOI:10.1016/0003-9861(84)90546-0
PMID:6547584
Abstract

A novel GDlb ganglioside which contains only N-glycolylneuraminic acid was isolated from bovine adrenal medulla by DEAE-Sephadex A-25 and Iatrobeads column chromatography. The concentration of this ganglioside was 0.9 nmol lipid-bound sialic acid per gram fresh tissue, which accounted for 2.7% of the disialoganglioside fraction. The structure was elucidated by sugar analysis, neuraminidase digestion, and permethylation studies. The complete structure of this ganglioside was identified as GDlb (NeuGc)2 or II3 (NeuGc)2-GgOse4Cer.

摘要

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