Linhartová A, Anderson A E, Foraker A G
Arch Pathol Lab Med. 1984 Aug;108(8):662-5.
To elucidate interrelations of airway inflammation and emphysema, bronchi from subjects with severe panlobular and centrilobular disease and normal lungs were compared. This disclosed an intense infiltration with chronic inflammatory cells, mucous gland hypertrophy, and thickening of bronchi, primarily in association with emphysema having a panlobular configuration. These changes complement a generalized thickening and inflammation of nonrespiratory bronchioles previously observed in these cases. We conclude that the panlobular pattern may be a close function of inflammatory thickening of the conductive airways to respective lungs and lung parts, but centrilobular emphysema is not reliant on these changes. The precursory defect for the centrilobular lesion instead has been shown to be a more peripherally oriented respiratory bronchiolitis around the centers of lobules.
为阐明气道炎症与肺气肿之间的相互关系，对患有严重全小叶型和小叶中心型疾病的受试者以及正常肺部受试者的支气管进行了比较。结果显示，主要在伴有全小叶型结构的肺气肿患者中，存在慢性炎症细胞的强烈浸润、黏液腺肥大以及支气管增厚。这些变化与之前在这些病例中观察到的非呼吸性细支气管的普遍增厚和炎症相互补充。我们得出结论，全小叶型模式可能与相应肺脏和肺部分的传导气道炎症性增厚密切相关，但小叶中心型肺气肿并不依赖于这些变化。相反，小叶中心型病变的前驱缺陷已被证明是围绕小叶中心更外周定向的呼吸性细支气管炎。
