Linhartová A, Anderson A E, Foraker A G
Arch Pathol Lab Med. 1982 Oct;106(10):499-502.
Our investigation of the radially affixed alveoli of nonrespiratory bronchioles showed that the interalveolar interval was basically constant for normal bronchioles of all sizes, with a mean value of 0.146 mm. The mean interalveolar interval increased significantly to 0.173 and 0.209 mm, respectively, in the two most severe grades of emphysema. The pattern of alveolar affixment to the walls of bronchioles was also altered in emphysema, with irregular interruptions, variations in size and shape of abutting luminal spaces, and loss of alveolar attachment surface. These changes reflected the disruptive phase of emphysema and corroborated previous studies. A dominant extrinsic force normally responsible for bronchiolar patency is thus compromised. Any bronchiole so affected would logically be prone to collapse or contracture of its wall, luminal deformities, diminution of luminal caliber, and retarded airflow.
我们对非呼吸性细支气管的放射状附着肺泡进行的研究表明，对于所有大小的正常细支气管，肺泡间隔基本恒定，平均值为0.146毫米。在两个最严重的肺气肿等级中，平均肺泡间隔分别显著增加到0.173毫米和0.209毫米。肺气肿时，肺泡附着于细支气管壁的模式也发生改变，出现不规则中断、相邻管腔空间大小和形状的变化以及肺泡附着表面的丧失。这些变化反映了肺气肿的破坏阶段，并证实了先前的研究。因此，通常负责细支气管通畅的主要外在力量受到损害。任何受此影响的细支气管在逻辑上都容易发生管壁塌陷或挛缩、管腔畸形、管腔口径减小以及气流受阻。
