Linhartová A, Anderson A E
Am Rev Respir Dis. 1983 Jan;127(1):42-5. doi: 10.1164/arrd.1983.127.1.42.
Histological measurements in cases of severe paniobular and centrilobular emphysema and in normal lungs disclosed a generalized thickening of the walls of small airways in the panlobular group. With mathematical models, this was depicted as a potential basis for airway closure at higher than normal lung volumes and trapping of air. Lungs with mixtures of panlobular and centrilobular emphysema predominate in the general population, and the obstructive component of airways in this setting is likely a net result of multiple lesions. These may be common in varying degrees to both varieties of disease but especially characteristic of one form. Bronchiolar thickening is one such general process. Present findings suggest that this is prone to be linked to emphysema with a panlobular pattern.
对重度全小叶型和小叶中心型肺气肿病例以及正常肺组织进行的组织学测量显示，全小叶型组中小气道壁普遍增厚。通过数学模型，这被描述为在高于正常肺容积时气道关闭和空气潴留的潜在基础。在普通人群中，以全小叶型和小叶中心型肺气肿混合存在的肺最为常见，在这种情况下气道的阻塞成分可能是多种病变的综合结果。这些病变在两种疾病中可能都不同程度地存在，但在其中一种类型中尤为典型。细支气管增厚就是这样一种常见过程。目前的研究结果表明，这易于与全小叶型肺气肿相关联。
