Young R S, Hessert T R, Pritchard G A, Yagel S K
Am J Obstet Gynecol. 1984 Sep 1;150(1):52-6. doi: 10.1016/s0002-9378(84)80109-x.
Recent reports suggest that naloxone, an opiate antagonist, may adversely affect the asphyxiated fetus. We found that naloxone exacerbated hypoxic-ischemic brain injury in the 7-day-old rat subjected to unilateral common carotid artery ligation and hypoxia. Moreover, there was no amelioration of systemic acidosis or brain edema in naloxone-treated animals compared to animals treated with saline solution. High doses of naloxone may reduce the resistance of the fetus to hypoxic stress.
近期报告表明，阿片类拮抗剂纳洛酮可能会对窒息胎儿产生不利影响。我们发现，纳洛酮会加重单侧颈总动脉结扎并缺氧处理的7日龄大鼠的缺氧缺血性脑损伤。此外，与用盐溶液处理的动物相比，用纳洛酮处理的动物的全身酸中毒或脑水肿并未得到改善。高剂量纳洛酮可能会降低胎儿对缺氧应激的抵抗力。
