Chernick V, Craig R J
Science. 1982 Jun 11;216(4551):1252-3. doi: 10.1126/science.7200636.
Pregnant near-term rabbits were given an intravenous dose of saline or the opiate antagonist naloxone and then asphyxiated. The fetuses were delivered by cesarean section and evaluated for respiration, color, muscle tone, response to stimulation, and general activity at 1, 3, 5, 10, 15, and 30 minutes of age. The naloxone-treated pups had significantly better scores during the first 15 minutes after birth than the saline-treated pups. Naloxone did not adversely affect the scores of nonasphyxiated pups. These data suggest that endogenous opiates worsen the neonatal depression caused by intrauterine asphyxia and that this effect can be reversed by naloxone.
给妊娠晚期的兔子静脉注射一剂生理盐水或阿片类拮抗剂纳洛酮，然后使其窒息。通过剖宫产取出胎儿，并在其出生后1、3、5、10、15和30分钟评估其呼吸、肤色、肌张力、对刺激的反应和总体活动情况。与接受生理盐水治疗的幼崽相比，接受纳洛酮治疗的幼崽在出生后的前15分钟内得分明显更高。纳洛酮对未窒息幼崽的评分没有不利影响。这些数据表明，内源性阿片类物质会加重宫内窒息引起的新生儿抑制，且这种作用可被纳洛酮逆转。
