Hayes J K, Westenskow D R, East T D, Jordan W S
Med Instrum. 1984 Jul-Aug;18(4):224-31.
A prototype Computer-Controlled Anesthesia Delivery System (CCADS) has been developed. The CCADS uses proportional, integral, and derivative (PID) software algorithms to control the delivery of oxygen, anesthetic agent,and nitrous-oxide (N2O) via the computer feedback control of precision mass-flow controller devices. The CCADS was evaluated in a group of seven dogs during 4 hours of closed-circuit enflurane N2O anesthesia. Throughout the 4-hour monitoring period, the CCADS maintained the animals' inspired oxygen concentration (FIO2), end-tidal enflurane concentration, and breathing circuit volume to within +/- 0.20, +/- 0.10 volume %, and +/- 30 ml/min (+/- 1 SD), respectively, of the desired values. The interactive software allowed selective graphic display of the 10-breath averaged data parameters, or modification of FIO2, end-tidal enflurane concentration, and breathing circuit volume, whenever animal re-evaluation during an anesthesia procedure was necessary.
一种计算机控制麻醉输送系统（CCADS）的原型已被开发出来。CCADS使用比例、积分和微分（PID）软件算法，通过精密质量流量控制器设备的计算机反馈控制来控制氧气、麻醉剂和一氧化二氮（N2O）的输送。在一组七只狗进行4小时的循环安氟醚N2O麻醉期间，对CCADS进行了评估。在整个4小时的监测期内，CCADS将动物的吸入氧浓度（FIO2）、呼气末安氟醚浓度和呼吸回路容积分别维持在期望值的±0.20、±0.10体积%和±30 ml/min（±1标准差）范围内。交互式软件允许在麻醉过程中需要对动物进行重新评估时，选择性地以图形方式显示10次呼吸的平均数据参数，或修改FIO2、呼气末安氟醚浓度和呼吸回路容积。
