Das G D
Acta Anat (Basel). 1978;101(3):225-33. doi: 10.1159/000144971.
Rat embryos were exposed to 170 r of X-ray irradiation on day 15 or 18 of gestation, and sacrificed when they reached the postnatal age of 30 days. In the cerebella of these animals, normal-looking and atrophied Purkinje cells were studied and compared with those observed in the cerebellum of the normal animals. The normal animals did not show presence of any atrophied Purkinje cells, but the X-ray-irradiated animals showed a lesser number of Purkinje cells and many atrophied Purkinje cells. In the cerebellum of animals that were X-ray-irradiated on day 15 of gestation, the number of Purkinje cells was only 32% of those in the normal cerebellum, and in those that received X-ray irradiation on day 18 of embryogenesis there were about 95.5% as many Prukinje cells as in the normal cerebellum. But, in the cerebella of animals in the latter group there were two to three times more atrophied Purkinje cells than in the cerebella of animals in the former group. These findings are discussed in terms of lasting effects of low-level X-ray irradiation in the form of premature atrophy and death of the Purkinje cells.
将妊娠第15天或18天的大鼠胚胎暴露于170伦琴的X射线辐射下，并在它们达到出生后30天龄时处死。在这些动物的小脑中，研究了外观正常和萎缩的浦肯野细胞，并与正常动物小脑中观察到的细胞进行了比较。正常动物未显示任何萎缩的浦肯野细胞，但接受X射线辐射的动物显示浦肯野细胞数量较少且有许多萎缩的浦肯野细胞。在妊娠第15天接受X射线辐射的动物小脑中，浦肯野细胞数量仅为正常小脑的32%，而在胚胎发育第18天接受X射线辐射的动物中，浦肯野细胞数量约为正常小脑的95.5%。但是，后一组动物小脑中萎缩的浦肯野细胞比前一组动物小脑中的多两到三倍。根据低水平X射线辐射以浦肯野细胞过早萎缩和死亡的形式产生的持久影响对这些发现进行了讨论。
