Morgenroth K
Fortschr Med. 1984 Oct 18;102(39):971-6.
The secretion of bronchiolar and bronchial epithelium was investigated in human biopsy material by electron microscopy. The secretion of Clara cells in the bronchioli of the goblet cells of bronchial epithelium and the secretion of peribronchial glands produce the gel phase of mucus above the bronchial mucosa. This gel phase is transported on the periciliary sol phase through the cilia beat, which consists of intercellular fluid. Foam-like, regularly arranged surfactant structures are detectable in this sol phase. Due to its surface-active qualities this surfactant, which is formed in the pneumocytes II of the alveolar system, has an anti-adhesive effect on the border between the sol and gel phase of the mucus. Furthermore, it contributes to the stabilisation of the water content in the sol phase, which is of decisive importance for the ciliary mucus transport. The morphological results agree with the results from the physiological and biochemical investigations, indicating that the surfactant has an important function in bronchiolar and bronchial clearance.
通过电子显微镜对人体活检材料中的细支气管和支气管上皮分泌进行了研究。支气管上皮杯状细胞在细支气管中的分泌以及支气管周围腺体的分泌在支气管黏膜上方产生黏液的凝胶相。该凝胶相通过由细胞间液组成的纤毛摆动在纤毛周围溶胶相上运输。在该溶胶相中可检测到泡沫状、规则排列的表面活性剂结构。由于其表面活性特性，这种在肺泡系统Ⅱ型肺细胞中形成的表面活性剂对黏液溶胶相和凝胶相之间的边界具有抗黏附作用。此外，它有助于溶胶相中水分含量的稳定，这对纤毛黏液运输至关重要。形态学结果与生理和生化研究结果一致，表明表面活性剂在细支气管和支气管清除中具有重要作用。
