[片剂中盐酸诺昔替林的极谱测定]
[Polarographic determination of noxiptilin hydrochloride in tablets].
作者信息
Albert K
出版信息
Pharmazie. 1984 Aug;39(8):548-50.
A direct current polarographic method is proposed for the determination of noxiptiline hydrochloride (1) in tablets. Electrochemical reduction of 1 in HCl (0.1 mol X 1(-1) yields by a 4e process a product identified as 10, 11-dihydro-5H-dibenzo[a,d]cyclohepten-5-amine. The relative standard deviation of the determination is 0.66% within the 10(-4) mol X 1(-1) range. The limit of detection is about 5 X 10(-6) mol X 1(-1). Individual tablet contents varied between 95.6 and 104.7%, conforming to the requirements of the monograph "Content Uniformity" U.S.P. XX.
提出了一种直流极谱法用于测定片剂中的盐酸诺昔替林（1）。在0.1mol·L⁻¹ HCl中，1通过4e过程进行电化学还原生成一种产物，鉴定为10,11-二氢-5H-二苯并[a,d]环庚烯-5-胺。在10⁻⁴mol·L⁻¹范围内测定的相对标准偏差为0.66%。检测限约为5×10⁻⁶mol·L⁻¹。各片含量在95.6%至104.7%之间，符合美国药典XX“含量均匀度”专论的要求。
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