巨皮质素对斯普拉格-道利大鼠全脑缺血的预防作用

Prevention by macrocortin of global cerebral ischemia in Sprague-Dawley rats.

作者信息

Koltai M, Tósaki A, Adám G, Joó F, Nemecz G, Szekeres L

出版信息

Eur J Pharmacol. 1984 Oct 15;105(3-4):347-50. doi: 10.1016/0014-2999(84)90630-7.

Abstract

We have previously shown that dexamethasone protects female Sprague-Dawley CFY rats against global cerebral ischemia induced by bilateral carotid artery ligation. In the present study, macrocortin derived from rat peritoneal cells exposed to dexamethasone was found to exhibit antiphospholipase A2 activity and to provide significant protection against the fatal consequences of carotid artery ligation. These results suggest that the cerebroprotective effect of glucocorticoids may be related to macrocortin production.

摘要

我们先前已表明，地塞米松可保护雌性斯普拉格-道利CFY大鼠免受双侧颈动脉结扎所致的全脑缺血损伤。在本研究中，发现源自暴露于地塞米松的大鼠腹膜细胞的巨皮质素具有抗磷脂酶A2活性，并能为颈动脉结扎的致命后果提供显著保护。这些结果表明，糖皮质激素的脑保护作用可能与巨皮质素的产生有关。