糖皮质激素可诱导抗炎和抗磷脂酶蛋白在大鼠腹腔内的形成与释放。
Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat.
作者信息
Blackwell G J, Carnuccio R, Di Rosa M, Flower R J, Langham C S, Parente L, Persico P, Russel-Smith N C, Stone D
出版信息
Br J Pharmacol. 1982 May;76(1):185-94. doi: 10.1111/j.1476-5381.1982.tb09205.x.
Abstract
1 Dexamethasone and hydrocortisone induced the release of anti-phospholipase proteins into the peritoneal cavities of rats. 2 Adrenocorticotrophic hormone (ACTH) also releases these proteins in normal but not in adrenalectomized rats. 3 Peritoneal lavage proteins were separated by ion-exchange and size exclusion chromatography. The anti-phospholipase activity occurred in four separate fractions with the major component having an apparent mol. wt. of 40 k. 4 Column fractions containing these anti-phospholipase proteins had anti-inflammatory effects in the rat carrageenin pleurisy model whereas other fractions were inactive. 5 The proteins appear to be identical to macrocortin and lipomodulin, the 'second messengers' of glucocorticoid hormone action on the arachidonate system.
摘要
- 地塞米松和氢化可的松可诱导抗磷脂酶蛋白释放到大鼠腹腔中。2. 促肾上腺皮质激素（ACTH）在正常大鼠中也能释放这些蛋白质，但在肾上腺切除的大鼠中则不能。3. 通过离子交换和尺寸排阻色谱法分离腹腔灌洗蛋白。抗磷脂酶活性存在于四个不同的组分中，主要成分的表观分子量为40k。4. 含有这些抗磷脂酶蛋白的柱馏分在大鼠角叉菜胶胸膜炎模型中具有抗炎作用，而其他馏分则无活性。5. 这些蛋白质似乎与大皮质素和脂调素相同，它们是糖皮质激素作用于花生四烯酸系统的“第二信使”。
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Hydrocortisone-induced inhibitor of prostaglandin biosynthesis in rat leucocytes.氢化可的松诱导的大鼠白细胞中前列腺素生物合成抑制剂
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Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases.风湿性疾病患者中存在针对磷脂酶抑制蛋白（脂调素）的自身抗体。
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Adrenal cortical and medullary hormones in recovery of tissues from local injury.肾上腺皮质和髓质激素在局部损伤组织恢复中的作用
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Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids.抑制细胞中花生四烯酸的释放作为抗炎皮质类固醇的生化作用。
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